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T22831 |
Protein kinase inhibitor H-7 dihydrochloride
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H-7 dihydrochloride |
PKC
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Protein kinase inhibitor H-7 dihydrochloride(H-7 dihydrochloride) is a potent protein kinase C (PKC) inhibitor. Protein kinase inhibitor H-7 dihydrochloride (100 μM) significantly inhibits TPA (skin tumor promoter, 12-O-... |
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T41267 |
PROTAC(H-PGDS)-7
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PROTAC(H-PGDS)-7 is a selective and potent small molecule hematopoietic prostaglandin D synthase (H-PGDS) PROTAC degradation agent that exhibits degradation activity in KU812 cells with a DC50 of 17.3 pM. PROTAC(H-PGDS)-... |
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T60109 |
Protein kinase inhibitor H-7
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5-(2-methylpiperazine-1-sulfonyl)isoquinoline,1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine |
PKC
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Protein kinase inhibitor H-7 (5-(2-methylpiperazine-1-sulfonyl)isoquinoline) is a potent inhibitor of protein kinase C (PKC) with a Ki of 6 μM. Protein kinase inhibitor H-7 is also a cyclic nucleotide dependent protein k... |
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T9308 |
AzoMethine-H Monosodium salt hydrate
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Sodium 5-hydroxy-4-((2-hydroxybenzylidene)amino)-7-sulfonaphthalene-2-sulfonate hydrate |
Others
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AzoMethine-H Monosodium salt hydrate (Sodium 5-hydroxy-4-((2-hydroxybenzylidene)amino)-7-sulfonaphthalene-2-sulfonate hydrate) is a reagent used for the colorimetric determination of boron in soil, plants, composts, manu... |
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T15458 |
H2DCFDA
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2',7'-Dichlorodihydrofluorescein diacetate,DCFH-DA |
Reactive Oxygen Species
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H2DCFDA (DCFH-DA) belongs to the class of green fluorescent dyes and is a probe for the detection of intracellular reactive oxygen species (ROS) (Ex/Em=488/525 nm) with cell membrane permeability. |
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T38766L |
Histone H3 (1-35) acetate
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Others
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Histone H3 (1-35) acetate is a 35-residue peptide of histone H3. Histone H3 is an important protein that plays a role in the dynamic and long term regulation of genes. |
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T7501 |
Iso-H7 dihydrochloride
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PKC
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Iso-H7 dihydrochloride is a less potent inhibitor of phosphokinase C than H-7. |
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T68950 |
Hepta-histidine
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Hepta-histidine is a novel inhibitor of Tau aggregation against Tau-related neurodegenerative diseases including Alzheimer's disease (AD). |
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T18998 |
H-L-Photo-lysine hydrochloride
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H-L-Photo-lysine hydrochloride (1253643-88-7 free base) |
Others
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H-L-Photo-lysine hydrochloride, a photo-cross-linker, is a diazirine-containing lysine amino acid. It can site-selective incorporated into proteins and is used to crosslink protein-protein interactions in vitro and in li... |
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T6928 |
Pantoprazole
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SKF96022,BY1023 |
Apoptosis
,
Proton pump
,
Autophagy
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Pantoprazole (BY1023) is a proton pump inhibitor used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. |
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TD0076 |
AMCA-H N-succinimidyl ester
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7-Hydroxy-4-methylcoumarin-3-acetic acid, succinimidyl ester |
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The amine-reactive AMCA, SE (7-amino-4-methylcoumarin-3-acetic acid, succinimidyl ester) and its conjugates yield blue-fluorescence (approximate excitation/emission maxima ~353/442) that can be used as a contrasting colo... |
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T0161 |
Pantoprazole Sodium Hydrate
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SKF96022 sodium hydrate,BY1023 (sodium hydrate),SKF96022 (sodium hydrate) |
Apoptosis
,
Potassium Channel
,
Proton pump
,
Autophagy
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Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. |
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T6929 |
Pantoprazole sodium
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Pantecta,SKF96022 sodium,SKF96022 (sodium),BY1023 (sodium),BY-1023 sodium,Pantoloc |
Apoptosis
,
Others
,
Proton pump
,
HIF
,
Autophagy
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Pantoprazole sodium (Pantecta) is the sodium salt form of a substituted benzimidazole with proton pump inhibitor activity. Pantoprazole sodium is a lipophilic, weak base that crosses the parietal cell membrane and enters... |
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T65404 |
(2'R,7R,8R,10S,13S,14S)-Methyl 10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,10,12,13,14,15,16-tetradecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-carboxylate
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(2'R,7R,8R,10S,13S,14S)-Methyl 10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,10,12,13,14,15,16-tetradecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-carboxylate is a useful organic compound for research related... |
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T67324 |
(1'R,3a'R,8a'S,9'S,9a'S)-1'-Methyl-3'-oxo-N,N-diphenyl-3',3a',5',7',8',8a',9',9a'-octahydro-1'H-spiro[[1,3]dioxolane-2,6'-naphtho[2,3-c]furan]-9'-carboxamide
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(1'R,3a'R,8a'S,9'S,9a'S)-1'-Methyl-3'-oxo-N,N-diphenyl-3',3a',5',7',8',8a',9',9a'-octahydro-1'H-spiro[[1,3]dioxolane-2,6'-naphtho[2,3-c]furan]-9'-carboxamide is a useful organic compound for research related to life scie... |
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T5178 |
AZ876
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Liver X Receptor
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AZ876 is a potent, highly selective LXR agonist with Ki/EC50 of 7/6 nM and 11/73 nM for hLXRα and hLXRβ respectively. |
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T6190 |
Telaprevir
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VX-950,LY-570310,Incivek,MP-424 |
HCV Protease
,
SARS-CoV
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Telaprevir (Incivek) (VX-950) is an effective inhibitor of HCV NS3-4A serine protease (IC50: 0.35 μM). |
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T35610 |
2,5-dimethyl Celecoxib
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Apoptosis
,
Wnt/beta-catenin
,
Prostaglandin Receptor
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2,5-dimethyl Celecoxib is a derivative of celecoxib that does not inhibit COX-2 (IC50 = >100 μM).1 It does inhibit microsomal prostaglandin E synthase-1 (mPGES-1) in HeLa cells (IC50 = 15.6 μM) and reduces prostaglandin ... |
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T65917 |
H-Asp(OtBu)-OH
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H-Asp(OtBu)-OH is a useful organic compound for research related to life sciences. The catalog number is T65917 and the CAS number is 3057-74-7. |
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T64934 |
H-HoLeu-OH
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H-HoLeu-OH is a useful organic compound for research related to life sciences. The catalog number is T64934 and the CAS number is 31872-98-7. |
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T65369 |
H-N-Me-D-Ala-OH
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H-N-Me-D-Ala-OH is a useful organic compound for research related to life sciences. The catalog number is T65369 and the CAS number is 29475-64-7. |
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T65226 |
H-D-Leu-Gly-OH
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H-D-Leu-Gly-OH is a useful organic compound for research related to life sciences. The catalog number is T65226 and the CAS number is 997-05-7. |
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T67585 |
H-Tyr-OtBu
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H-Tyr-OtBu is a useful organic compound for research related to life sciences. The catalog number is T67585 and the CAS number is 16874-12-7. |
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T64757 |
H-Glu-OtBu
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H-Glu-OtBu is a useful organic compound for research related to life sciences. The catalog number is T64757 and the CAS number is 45120-30-7. |
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T65897 |
H-D-Phe(4-CN)-OH
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H-D-Phe(4-CN)-OH is a useful organic compound for research related to life sciences. The catalog number is T65897 and the CAS number is 263396-44-7. |
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T66206 |
H-D-Phe(2-Cl)-OH
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H-D-Phe(2-Cl)-OH is a useful organic compound for research related to life sciences. The catalog number is T66206 and the CAS number is 80126-50-7. |
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T64920 |
H-D-Glu(OMe)-OH
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H-D-Glu(OMe)-OH is a useful organic compound for research related to life sciences. The catalog number is T64920 and the CAS number is 6461-04-7. |
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T37053 |
Z-(L-Arg)-AMC (hydrochloride)
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Z-(L-Arg)-AMC is a fluorogenic substrate for trypsin, cathepsin B, and cathepsin H.1,2Upon enzymatic cleavage by trypsin, cathepsin B, or cathepsin H, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can b... |
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T61032 |
Carbonic anhydrase inhibitor 10
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Carbonic anhydrase inhibitor 10 can be used in the research of cancer that shows anti-proliferative activity against MCF-7 cancer cell line with an IC50 of 11.9 μM. Carbonic anhydrase inhibitor 10 is a potent inhibitor o... |
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T69589 |
PX-316
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PX-316 is a AKT inhibior. PX-316, when administered intraperitoneally to mice at 150 mg/kg, inhibits Akt activation in HT-29 human tumor xenografts up to 78% at 10 h with recovery to 34% at 48 h. PX-316 has antitumor act... |
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T64553 |
GLP-1(7-37) TFA salt
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The truncated glucagon-like peptides GLP-1(7-37) is naturally occurring peptide product of the preproglucagon gene that are synthesized primarily in the intestine and acts as incretin that are released from the intestine... |
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T35582 |
H-Arg-Gly-Asp-Cys-OH (trifluoroacetate salt)
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H-Arg-Gly-Asp-Cys-OH is a tetrapeptide that contains the arginine-glycine-aspartate (RGD) motif, a sequence that acts as a recognition site for various adhesion proteins.1It inhibits the binding of fibrinogen to endothel... |
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T36024 |
FR179642 (hydrate)
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FR179642 (hydrate) |
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FR179642 is the cyclic peptide nucleus of the lipopeptide antifungal FR901379 and an intermediate in the synthesis of the echinocandin antifungal FK463 .1,2
1.Tomishima, M., Ohki, H., Yamada, A., et al.FK463, a novel wat... |
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T35428 |
β-Rubromycin
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β-Rubromycin is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities.1 It inhibits the growth of HMO2, KATO-III, and MCF-7 cells with GI50 values of 0.5, 0.84, and <0.1 μM, ... |
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T35451 |
β-Defensin-2 (human) (trifluoroacetate salt)
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β-Defensin-2 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1It inhibits the growth of periodontopathogenic and cari... |
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T36991 |
Monascuspiloin
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Monascuspiloin is a fungal metabolite that has been found inM. pilosusM93-fermented rice.1It induces endoplasmic reticulum stress and autophagy in PC3 prostate cancer cells. Monascuspiloin (15-45 μM) decreases viability ... |
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T36296 |
BIO5192 hydrate
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BIO5192 hydrate is a selective and potent integrin α4β1 (VLA-4) inhibitor (Kd<10 pM). BIO5192 hydrate selectively binds to α4β1 (IC50=1.8 nM) over a range of other integrins. BIO5192 hydrate results in a 30-fold increase... |
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T35527 |
PI3Kα-IN-4
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PI3Kα-IN-4 |
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PI3Kα-IN-4 is a potent, selective, and orally active PI3Kα inhibitor, demonstrating an IC50 of 1.8 nM and exhibiting antitumor activity[1]. |
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T35488 |
(S)-PI3Kα-IN-4
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(S)-PI3Kα-IN-4 |
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(S)-PI3Kα-IN-4 is a potent inhibitor of PI3Kα, with an IC50 of 2.3 nM. (S)-PI3Kα-IN-4 shows 38.3-, 4.25-, and 4.93-fold selectivity for PI3Kα over PI3Kβ, PI3Kδ, and PI3Kγ, respectively. (S)-PI3Kα-IN-4 can be used for the... |
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T37522 |
Teneligliptin
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Teneligliptin (MP-513) is a potent chemotype prolylthiazolidine-based DPP-4 inhibitor, which competitively inhibits human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50s of approximately 1 nM.
Teneli... |
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T36978 |
AS-99 TFA
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AS-99 TFA is a first-in-class, potent and selective ASH1L histone methyltransferase inhibitor (IC50= 0.79 μM, Kd= 0.89 μM) with anti-leukemic activity. AS-99 TFA blocks cell proliferation, induces apoptosis and different... |
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T35771 |
Destruxin B2
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Destruxin B2 is a cyclic hexadepsipeptide mycotoxin that has been found in M. anisopliae and has antiviral, insecticidal, and phytotoxic activities.1,2,3 It inhibits secretion of hepatitis B virus surface antigen (HBsAg)... |
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T37594 |
Pericosine A
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Pericosine A is a fungal metabolite that has been found inP. byssoidesand has anticancer activity.1It inhibits the growth of a variety of cancer cells, including breast, colon, lung, ovary, stomach, and prostate cell lin... |
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T35560 |
SAR502250
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SAR502250 is a potent, selective, ATP-competitive, orally active, and brain-penetrant GSK3 inhibitor with a human GSK-3β IC50 value of 12 nM. It exhibits antidepressant-like activity and is being researched for potential... |
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T35799 |
MBX-8025 (sodium salt)
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MBX-8025 is an agonist of peroxisome proliferator-activated receptor δ (PPARδ).1 It is greater than 750- and 2,500-fold selective for PPARδ over PPARα and PPARγ. MBX-8025 (10 mg/kg per day for eight weeks) reduces increa... |
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T36880 |
NHC-diphosphate
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NHC-diphosphate, a phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) in its diphosphate form[1], serves as a potent antiviral agent. As a pyrimidine ribonucleoside, NHC effectively counters the repl... |
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T36881 |
NHC-diphosphate triammonium
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NHC-triphosphate triammonium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) as a triphosphate form[1]. NHC-triphosphate triammonium is a weak alternative substrate for the viral poly... |
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T37736 |
N-cis-hexadec-9Z-enoyl-L-Homoserine lactone
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N-(2-oxotetrahydrofuran-3S-yl) Palmitoleyl Amide,N-cis-hexadec-9Z-enoyl-L-Homoserine lactone |
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Quorum sensing is a regulatory process used by bacteria for controlling gene expression in response to increasing cell density.[1] This regulatory process manifests itself with a variety of phenotypes including biofilm f... |
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T35698 |
Octanoic Acid-13C
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Octanoic acid-13C is intended for use as an internal standard for the quantification of octanoic acid by GC- or LC-MS. Octanoic acid is a medium-chain saturated fatty acid. It has been found in Teleme cheeses made from g... |
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T35591 |
Guanfacine-13C,15N3
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Guanfacine-13C,15N3 |
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Guanfacine-13C,15N3is intended for us as an internal standard for the quantification of guanfacine by GC- or LC-MS. Guanfacine is an α2-adrenergic receptor (α2-AR) agonist with Kivalues of 93, 1,380, and 3,890 nM for α2A... |
